“What to Know About Zepbound (Tirzepatide), the New Mounjaro-Like Weight Loss Drug”

An obesity specialist shares insights on this potent GLP-1 and GIP receptor agonist, which promotes even greater weight loss than rival injectables Wegovy and Ozempic (semaglutide). The approval by the U.S. Food and Drug Administration (FDA) of the weight loss drug Zepbound (tirzepatide) will give millions of Americans with overweight and obesity a powerful new option for shedding excess pounds. Zepbound, a once-weekly injected medicine with the same active ingredient as the popular type 2 diabetes drug Mounjaro, was cleared by the FDA for chronic weight management by adults with obesity, and by adults with overweight plus at least one weight-related health issue such as high blood pressure, type 2 diabetes, or elevated cholesterol. Tirzepatide, the active ingredient in Zepbound and Mounjaro, is the first drug in a new family of medicines that target two hormones — glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) — that are involved in maintaining healthy blood sugar levels and sending signals of satiety from the gut to the brain.